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BAD

Другие языки:

BAD

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BAD

ساختارهای موجود

PDB

جستجوی هم‌ساخت‌شناسی: PDBe RCSB

فهرست شناسه‌های PDB
1G5J

معین‌کننده‌ها

نام‌های دیگر

BAD, BBC2, BCL2L8, BCL2 associated agonist of cell death

شناسه‌های بیرونی

OMIM: 603167 MGI: 1096330 HomoloGene: 3189 GeneCards: BAD

موقعیت ژن (موش)

کروموزوم	کروموزوم ۱۹ (موش)

نوار	19\|19 A	شروع	6,919,229 bp
نوار	19\|19 A	پایان	6,929,267 bp

الگوی گسترش RNA

More reference expression data

هستی‌شناسی ژن
عملکرد ملکولی	• 14-3-3 protein binding • protein phosphatase binding • GO:0001948، GO:0016582 پیوند پروتئینی • protein heterodimerization activity • cysteine-type endopeptidase activator activity involved in apoptotic process • phospholipid binding • protein kinase binding • lipid binding • protein phosphatase 2B binding • protein kinase B binding
ترکیبات سلولی	• سیتوپلاسم • سیتوزول • membrane • mitochondrial outer membrane • میتوکندری
فرایند زیستی	• positive regulation of T cell differentiation • cellular response to hypoxia • regulation of apoptotic process • response to amino acid • response to estradiol • response to hypoxia • positive regulation of type B pancreatic cell development • GO:1904578 response to organic cyclic compound • extrinsic apoptotic signaling pathway • positive regulation of autophagy • glucose homeostasis • cytokine-mediated signaling pathway • response to testosterone • positive regulation of epithelial cell proliferation • positive regulation of B cell differentiation • response to progesterone • positive regulation of apoptotic process by virus • pore complex assembly • cellular response to nicotine • response to glucocorticoid • positive regulation of neuron death • response to glucose • regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to organic substance • response to calcium ion • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • ATP metabolic process • cellular response to mechanical stimulus • activation of cysteine-type endopeptidase activity • regulation of mitochondrial membrane permeability • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway • positive regulation of glucokinase activity • اسپرماتوژنز • glucose catabolic process • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of proteolysis • cerebral cortex development • extrinsic apoptotic signaling pathway in absence of ligand • cellular response to lipid • positive regulation of release of cytochrome c from mitochondria • response to hormone • positive regulation of mitochondrial membrane potential • positive regulation of insulin secretion involved in cellular response to glucose stimulus • suppression by virus of host apoptotic process • response to ethanol • ADP metabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell population proliferation • type B pancreatic cell proliferation • cellular response to chromate • extrinsic apoptotic signaling pathway via death domain receptors • response to hydrogen peroxide • response to oleic acid • release of cytochrome c from mitochondria • positive regulation of insulin secretion • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته • intrinsic apoptotic signaling pathway • apoptotic signaling pathway • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • positive regulation of apoptotic process • positive regulation of granulosa cell apoptotic process
منابع: آمیگو / کوئیک‌گو

هم‌ساخت‌شناسی

گونه‌ها

انسان

موش

Entrez


572


12015

آنسامبل


ENSG00000002330


ENSMUSG00000024959

یونی‌پروت


Q92934


Q61337

RefSeq (mRNA)


NM_004322 NM_032989، NM_004322


NM_001285453 NM_007522، NM_001285453

RefSeq (پروتئین)


NP_116784 NP_004313، NP_116784


NP_031548 NP_001272382، NP_031548

موقعیت (UCSC)

ن/م

جستجوی PubMed

Pro-apoptotic Bcl-2 protein, BAD

کمپلکس ترکیبی مولکول bcl-xl با پپتیدی از پروتئینِ BAD

شناسه‌ها

نماد

Bcl-2_BAD

ساختارهای پروتئینی در دسترس:
پی‌فم	structures / ECOD
پی‌دی‌بی	RCSB PDB; PDBe; PDBj
پی‌دی‌بی‌سام	structure summary

آگونیست مرگ سلول مرتبط با لنفوم ۲ لنفوسیت‌های بی (انگلیسی: Bcl-2-associated death promoter) یک پروتئین است که در انسان توسط ژن «BAD» کُدگذاری می‌شود.

این پروتئین القاکنندهٔ آپوپتوز سلولی و عضوی از خانوادهٔ BH3 (از زیرگروه‌های خانواده Bcl-2) است با این تفاوت که بر خلاف بیشتر اعضای این خانواده، فاقد دومِـین کربوکسیل تراغشایی در لایهٔ خارجی میتوکندری و هسته سلول است.

مشارکت‌کنندگان ویکی‌پدیا. «Bcl-2-associated death promoter». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر

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پیوند به بیرون

bcl-Associated Death Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم BAD انسانی و صفحهٔ جزئیات ژنی BAD در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.