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گیرنده هورمون آزادکننده هورمون رشد
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گیرنده هورمون آزادکننده هورمون رشد

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GHRHR
ساختارهای موجود
PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگر GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
شناسه‌های بیرونی OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
هم‌ساخت‌شناسی
گونه‌ها انسان موش
Entrez

2692

14602
آنسامبل

ENSG00000106128

ENSMUSG00000004654
یونی‌پروت

Q02643

P32082
RefSeq (mRNA)

NM_001009824 NM_000823، NM_001009824

XM_036165843 NM_001003685، XM_036165843
RefSeq (پروتئین)

NP_000814

XP_036021736 NP_001003685، XP_036021736
موقعیت (UCSC) ن/م Chr : 55.35 – 55.37 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

گیرنده هورمون آزادکننده هورمون رشد (انگلیسی: Growth-hormone-releasing hormone receptor) نوعی گیرنده جفت‌شونده با پروتئین جی است که به هورمون آزادکننده هورمون رشد اتصال می‌یابد و کارش را از طریق آدنیلات سیکلاز به انجام می‌رساند.

این ژن در غدهٔ هیپوفیز بیان می‌شود و در نهایت موجب رهاسازی هورمون رشد می‌گردد.

داروی سی‌جی‌سی ۱۲۹۵ یک آگونیست این گیرنده است.

برای مطالعهٔ بیشتر

  • Gaylinn BD (Apr 1999). "Molecular and cell biology of the growth hormone-releasing hormone receptor". Growth Hormone & IGF Research. 9 Suppl A: 37–44. doi:10.1016/S1096-6374(99)80008-2. PMID 10429879.
  • Lin-Su K, Wajnrajch MP (Dec 2002). "Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor". Reviews in Endocrine & Metabolic Disorders. 3 (4): 313–23. doi:10.1023/A:1020949507265. PMID 12424433.
  • Mayo KE (Oct 1992). "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone". Molecular Endocrinology. 6 (10): 1734–44. doi:10.1210/me.6.10.1734. PMID 1333056.
  • Squire J, Zhou A, Hassel BA, Nie H, Silverman RH (Jan 1994). "Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25". Genomics. 19 (1): 174–5. doi:10.1006/geno.1994.1033. PMID 7514564.
  • Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B, Kishimoto T (Oct 1995). "Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 80 (10): 2933–9. doi:10.1210/jc.80.10.2933. PMID 7559877.
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  • Gaylinn BD, Harrison JK, Zysk JR, Lyons CE, Lynch KR, Thorner MO (Jan 1993). "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone". Molecular Endocrinology. 7 (1): 77–84. doi:10.1210/me.7.1.77. PMID 7680413.
  • Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO (Jan 1994). "Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization". Genomics. 19 (1): 193–5. doi:10.1006/geno.1994.1045. PMID 8188233.
  • Wajnrajch MP, Gertner JM, Harbison MD, Chua SC, Leibel RL (Jan 1996). "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse". Nature Genetics. 12 (1): 88–90. doi:10.1038/ng0196-88. PMID 8528260.
  • Netchine I, Talon P, Dastot F, Vitaux F, Goossens M, Amselem S (Feb 1998). "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 83 (2): 432–6. doi:10.1210/jc.83.2.432. PMID 9467553.
  • Petersenn S, Rasch AC, Heyens M, Schulte HM (Feb 1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Molecular Endocrinology. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665.
  • Maheshwari HG, Silverman BL, Dupuis J, Baumann G (Nov 1998). "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh". The Journal of Clinical Endocrinology and Metabolism. 83 (11): 4065–74. doi:10.1210/jc.83.11.4065. PMID 9814493.
  • Salvatori R, Hayashida CY, Aguiar-Oliveira MH, Phillips JA, Souza AH, Gondo RG, Toledo SP, Conceicão MM, Prince M, Maheshwari HG, Baumann G, Levine MA (Mar 1999). "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 84 (3): 917–23. doi:10.1210/jc.84.3.917. PMID 10084571.
  • Morel G, Gallego R, Boulanger L, Pintos E, Garcia-Caballero T, Gaudreau P (Aug 1999). "Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries". Neuroendocrinology. 70 (2): 128–36. doi:10.1159/000054467. PMID 10461027.
  • Rekasi Z, Czompoly T, Schally AV, Halmos G (Sep 2000). "Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers". Proceedings of the National Academy of Sciences of the United States of America. 97 (19): 10561–6. doi:10.1073/pnas.180313297. PMC 27064. PMID 10962031.
  • Salvatori R, Fan X, Phillips JA, Espigares-Martin R, Martin De Lara I, Freeman KL, Plotnick L, Al-Ashwal A, Levine MA (Jan 2001). "Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib". The Journal of Clinical Endocrinology and Metabolism. 86 (1): 273–9. doi:10.1210/jc.86.1.273. PMID 11232012.
  • Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL (Jan 2002). "Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 196–200. doi:10.1073/pnas.012590999. PMC 117538. PMID 11773624.
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  • Plonowski A, Schally AV, Busto R, Krupa M, Varga JL, Halmos G (Jun 2002). "Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers". Peptides. 23 (6): 1127–33. doi:10.1016/S0196-9781(02)00043-8. PMID 12126741.

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